Scientists develop Tissue Healing Gel using milk-derived extracellular vesicles

 

         

Scientists at Columbia University have developed an injectable hydrogel for tissue repair that uses extracellular vesicles (EVs) derived from milk, including a byproduct of yogurt. The research, published in the journal Matter, showcases a novel approach to regenerative medicine that leverages a readily available and cost-effective source.

Here are some key details about this development:

 * What are milk-derived EVs? Extracellular vesicles are tiny particles naturally secreted by cells that contain various biological signals like proteins and genetic material. They are crucial for communication between cells. The researchers found that EVs from milk and yogurt not only have inherent regenerative potential but can also be used as a structural component to form the hydrogel.

     

     

 * How does the gel work? The injectable hydrogel is created by crosslinking these milk-derived EVs with biocompatible polymers. This allows the material to mimic the mechanics of living tissue and actively engage with surrounding cells to promote healing. Unlike some other biomaterials, this gel does not require additional chemical additives.

 * Healing potential: In early experiments on mice, the hydrogel demonstrated significant results. Within one week, it promoted the formation of new blood vessels, a process known as angiogenesis, which is vital for effective tissue regeneration. The material also fostered an anti-inflammatory immune response.

    

     

 * Advantages of this approach: The use of milk-derived EVs offers several benefits. They are a safe, abundant, and low-cost source compared to other EV sources. The injectable nature of the hydrogel allows for precise, local delivery to damaged tissue. The research also shows that the hydrogel platform is versatile and can be used with EVs from different sources.

This research represents a promising step toward developing new and accessible therapeutic materials for wound healing and regenerative medicine, particularly in areas where current treatments fall short in promoting long-term tissue repair.